Research
Understanding the genetic and molecular mechanisms of disease and biological functions through the integration of multi-omics
Comprehensive Insight into Disease Mechanisms: Integrating multi-omics data (genomics, transcriptomics, proteomics, metabolomics, and epigenomics) provides a holistic view of how genetic variations, gene expression changes, and molecular interactions contribute to disease development and progression.
Enhanced Understanding of Biological Functions: By combining different omics layers, we can uncover the complex interactions between genes, proteins, and metabolites, offering a deeper understanding of normal biological processes and how disruptions in these processes lead to diseases.
Understanding the mechanisms of transcriptional regulation through the integration of various functional genomics approaches
Uncovering Transcriptional Regulation Mechanisms: Integrating diverse functional genomics approaches, such as transcriptomics, chromatin accessibility, and epigenomic profiling, allows for a comprehensive understanding of how gene expression is regulated at the transcriptional level.
Elucidating Regulatory Networks: This integration helps identify key regulatory elements, such as transcription factors and enhancers, and their interactions with gene promoters, providing insights into how these interactions control gene expression and contribute to cellular function and disease.
Understanding the role of gene-environment interactions in biological functions
Clarifying Gene-Environment Interactions: Investigating how genetic predispositions interact with environmental factors, such as diet and lifestyle, helps us understand how these interactions influence biological processes and contribute to health and disease.
Revealing Mechanistic Insights: By studying these interactions, we can uncover how environmental exposures modulate gene expression and function, leading to a better understanding of complex traits and diseases influenced by both genetic and environmental components.